Interplay of KIR2DL5, nitric oxide, and tobacco smoking in predisposition to bladder cancer
KIR2DL5 is independently associated with BC, regardless of age, sex, or tobacco smoking status. While the immunological mechanisms remain unclear, enhanced nitric oxide production by immune effector cells may play a role in this association.
Authors
- Laia Egea
- G Server
- Francisco Boix (ORCID: https://orcid.org/0000-0002-3926-7920)
- José A. Campillo (ORCID: https://orcid.org/0000-0002-6541-0700)
- Alicia López-Abad (ORCID: https://orcid.org/0000-0003-1190-2694)
- Lourdes Gimeno (ORCID: https://orcid.org/0000-0002-3402-5842)
- María D Martínez-Hernández
- Pablo Guzmán (ORCID: https://orcid.org/0000-0001-5847-7248)
- Inmaculada Ruiz-Lorente (ORCID: https://orcid.org/0009-0009-2433-8755)
- Belén Ferri
- Francisco Galindo (ORCID: https://orcid.org/0000-0003-0826-6084)
- Tomás Fernández Aparicio (ORCID: https://orcid.org/0000-0001-5925-4900)
- Alfredo Minguela (ORCID: https://orcid.org/0000-0003-2472-5893)
- Pedro López Cubillana
- Juan Moreno Avilés
- María V. Martínez‐Sánchez
- Gloria Doñate Iñiguez
Institutions
- Universitat Jaume I (ES)
- Generalitat Valenciana (ES)
- Hospital General Universitario Morales Meseguer (ES)
- Hospital Reina Sofía de Murcia (ES)
- Hospital General Universitario Los Arcos del Mar Menor (ES)
- Santa Lucía University General Hospital (ES)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fcell.2025.1632101
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Fundación Séneca
- Fundación Científica Asociación Española Contra el Cáncer
- Universidad de Murcia
- Instituto de Salud Carlos III