Liver fat volume fraction assessment in medium and large anthropomorphic phantoms–dual energy virtual monochromatic imaging versus single‐energy CT

The validity of linear assumption about the FVF-HU relationship was found to depend on x-ray beam energy, VMI energy, and patient size, which impacts the FVF assessment accuracy. The settings resulting in best accuracy were identified. For the medium-sized phantom, the use of VMI with wider dual energy spectral separation showed the RMS errors ∼2.5%. For the large phantom, the use of single energy at 140 kV on the FKVS CT showed the best estimate, albeit with a RMS error of 9.2%.