Xiaoyao San's dual efficacy in NAFLD and depression: Unraveling the mechanisms via network pharmacology and multi-omics
XYS exerts therapeutic effects on NAFLD and depression through multi-target regulation, primarily by modulating the PPARα/HMOX1/GPX4 axis to inhibit ferroptosis. This study provides a novel mechanistic basis for the dual therapeutic efficacy of XYS.
Authors
- Jiaojian Lv
- Xiaofen Ni
- Chuxiao Shao (ORCID: https://orcid.org/0000-0002-7154-1723)
- Ayesha Younas (ORCID: https://orcid.org/0000-0002-4607-9979)
- X. X. Ding (ORCID: https://orcid.org/0009-0007-1216-1011)
- Zhiyong Li (ORCID: https://orcid.org/0000-0002-6814-9165)
- Yunxiao Liu (ORCID: https://orcid.org/0000-0003-4086-5044)
- Xiaoning Sun (ORCID: https://orcid.org/0000-0002-3399-7615)
- Shuanghu Wang (ORCID: https://orcid.org/0000-0001-5042-0650)
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Lishui University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
- Lishui Central Hospital (CN)
- Lishui City People's Hospital (CN)
- Dongfeng General Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.phymed.2025.157221
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03