Effect of Breast Surgery on Quality of Life in BRCA Mutation Carriers With Invasive Breast Cancer: A CANTO Database Study
When feasible, BCS should be preferred for BRCA1/2 mutation carriers, as it best preserves QoL. For patients requiring mastectomy, IBR is a valuable option, while DBR offers long-term benefits in body image and psychosocial well-being. Psychological support and structured postsurgical rehabilitation are strongly recommended to alleviate symptoms and optimize patient quality of life.
Authors
- Anne‐Laure Martin (ORCID: https://orcid.org/0000-0002-9302-8576)
- Christophe Gaudin (ORCID: https://orcid.org/0000-0002-6326-4551)
- Olivier Trédan (ORCID: https://orcid.org/0000-0001-5881-9383)
- W. Jacot
- Carole Tarpin (ORCID: https://orcid.org/0009-0003-9806-9662)
- Marion Fournier (ORCID: https://orcid.org/0000-0001-5718-1509)
- Guillaume Constantin
- Stéphanie Guillermet
- Katia Mahiou (ORCID: https://orcid.org/0000-0002-7309-4891)
- Alexia Kieffer (ORCID: https://orcid.org/0009-0004-5735-195X)
- Claire Bonneau (ORCID: https://orcid.org/0000-0001-6251-286X)
- Marie‐Ange Mouret‐Reynier (ORCID: https://orcid.org/0000-0001-5542-5813)
- Mario Campone (ORCID: https://orcid.org/0000-0002-5196-5908)
- Aurélie Bertaut (ORCID: https://orcid.org/0000-0002-7934-9509)
- Baptiste Sauterey (ORCID: https://orcid.org/0000-0001-9160-7307)
- Thierry Petit (ORCID: https://orcid.org/0000-0003-1968-1056)
- Charles Coutant (ORCID: https://orcid.org/0000-0003-4355-7012)
- F. Lerebours
Institutions
- Université de Montpellier (FR)
- Institut de Cancérologie Strasbourg (FR)
- Centre Georges François Leclerc (FR)
- Institut de Cancérologie de Lorraine (FR)
- Centre Léon Bérard (FR)
- Institut de Cancérologie de l'Ouest (FR)
- Centre Eugène Marquis (FR)
- Centre Jean Perrin (FR)
- Institut Bergonié (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- UniCancer Group (FR)
- Institut Paoli-Calmettes (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Clinical Breast Cancer
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.clbc.2025.09.001
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00