Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial
Preoperative supplementation with a combination of HMB, glutamine, and arginine was effective in reducing preoperative TNF-α levels in older patients undergoing cardiac surgery, suggesting a potential anti-inflammatory effect. This anti-inflammatory effect suggests a potential mechanism for improving postoperative outcomes and warrants further investigation. Registration number of Clinical Trial: UMIN000030490 (https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034773).
Authors
- Michiko Takahashi (ORCID: https://orcid.org/0000-0002-5422-2990)
- Tomoya Yamashita (ORCID: https://orcid.org/0000-0003-0267-3842)
- Takeshi Inoue (ORCID: https://orcid.org/0000-0001-5248-1289)
- Sei Saitoh (ORCID: https://orcid.org/0000-0001-6072-4287)
- Masato Ogawa (ORCID: https://orcid.org/0000-0002-4165-0267)
- Kumiko Wakida
- Takumi Hirabayashi (ORCID: https://orcid.org/0009-0004-9824-4341)
- Naofumi Yoshida (ORCID: https://orcid.org/0000-0003-3949-0089)
- Kodai Komaki (ORCID: https://orcid.org/0000-0002-1987-4360)
- Seimi Satomi‐Kobayashi (ORCID: https://orcid.org/0000-0003-4656-260X)
- Yoshitada Sakai (ORCID: https://orcid.org/0000-0002-0435-8398)
- Ken-ichi Hirata
Institutions
- Kobe University Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- Journal of Cardiology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jjcc.2025.08.017
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science