Diagnostic performance of left ventricular strain for predicting physiologically significant coronary artery disease

While the average LV GLS is not a robust predictor of physiologically significant CAD, the ischemic Bull's-eye pattern derived from LV GLS offers high sensitivity and negative predictive value. When combined with central aortic pulse pressure, this approach enhances the diagnostic accuracy for physiologically significant CAD. These findings support the integration of ischemic Bull's-eye patterns derived from LV GLS and central aortic pulse pressure into initial CAD screening protocols.