Trimethylamine-N-oxide damages astrocytes and lymphatic endothelial cells in the cerebral lymphatic system
TMAO can activate the NF-κB signaling pathway and damage the cellular function of brain glymphatic system and meningeal lymphatic vessels, and promote intracranial inflammation and SNCA deposition in mice, which may be a potential mechanism for TMAO involvement in neurodegenerative diseases.
Authors
- Xiao-Man Shi
- Hongxia Duan (ORCID: https://orcid.org/0000-0003-3995-1228)
- Meilan Su
- W H Tan
- Juan Zeng (ORCID: https://orcid.org/0000-0001-8227-0415)
- Yuan Chang (ORCID: https://orcid.org/0009-0004-5115-9668)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5476-1524)
- Song Wang (ORCID: https://orcid.org/0000-0002-8569-4325)
- Qinglin Wang
Institutions
- Chongqing University (CN)
- Chongqing Three Gorges Central Hospital (CN)
- Chongqing Three Gorges University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.ibneur.2025.09.001
- Citations
- 4
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 3.64
Funders
- Chongqing University