HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis
Our findings indicate that aberrant biomechanical force induces HDAC3 upregulation, which suppresses Nrf2-mediated transactivation of GDF11, thereby promoting chondrocyte adipogenesis and exacerbating TMJ OA progression.
Authors
- Peinan Fan
- Ying Zhan (ORCID: https://orcid.org/0000-0003-0693-1941)
- Feng He
- Fan Wu (ORCID: https://orcid.org/0000-0002-0495-6814)
- Qinghua Li (ORCID: https://orcid.org/0000-0002-4547-8513)
- Zhihua Xu (ORCID: https://orcid.org/0000-0002-3517-2393)
- Qian Liu (ORCID: https://orcid.org/0000-0002-6986-5542)
- Mian Zhang (ORCID: https://orcid.org/0000-0003-2464-361X)
- Hongyun Zhang (ORCID: https://orcid.org/0000-0002-5784-4787)
- Shibin Yu (ORCID: https://orcid.org/0000-0001-8428-1249)
- Yuqian Shi (ORCID: https://orcid.org/0000-0001-5782-7234)
- Fa He (ORCID: https://orcid.org/0000-0002-1843-016X)
- Helin Wang (ORCID: https://orcid.org/0000-0002-7059-4217)
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
- Air Force General Hospital PLA (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.09.002
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China