Artemisinin alleviates Parkinson’s disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats
Artemisinin mediates neuroprotection against Parkinson's disease via regulation of Adcy5-Gch1-BH4 axis in rats. These findings present a beneficial potential for future application of artemisinin on Parkinson's disease treatment.
Authors
- Daidi Li
- Xin-xing Yang
- Guoqing Wang (ORCID: https://orcid.org/0000-0002-9121-9571)
- Feng Zhang (ORCID: https://orcid.org/0000-0003-1122-3640)
- Wen Qian (ORCID: https://orcid.org/0000-0001-6600-8249)
- Yujia Zhao (ORCID: https://orcid.org/0000-0002-1032-8072)
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1186/s13059-025-03712-5
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Guizhou Science and Technology Department
- Ministry of Education, Science and Technology
- School of Pharmacy, Fudan University