Synthesis and Biological Evaluation of Some Novel 3‐Thioether‐Linked 1,2,4‐Triazole‐Furoate Hybrids

ABSTRACT Herein, we report the successful synthesis of some novel 3‐thioether‐linked 1,2,4‐triazole‐furoate hybrids ( 2a–f and 3a–c ) in excellent yields. Structural characterization of all the compounds was accomplished via NMR spectroscopy and X‐ray crystallography for 2f (CCDC No. 2457105), confirming the formation of the target hybrids. Biological evaluation revealed notably diverse bioactivities: antiproliferative activities of all the compounds against PANC‐1 and three compounds against Huh7 cells were evaluated via CCK‐8 assay, with 3c showing obvious efficacy (IC 50 = 20.37 μg/mL against Huh7). Significantly, 2a displayed potent growth‐promoting effects on the Gram‐negative bacterium Pseudomonas aeruginosa and the fungus Candida albicans , with remarkable promotion rates of 5525.00% and 500%, respectively. In contrast, it exhibited moderate inhibitory effects against Staphylococcus aureus (31.25%), Escherichia coli (55.56%), and Klebsiella pneumoniae (18.75%). 2b , 2d , 2f , and 3b showed remarkable growth‐promoting effects on both wheat stalks and radicles at a concentration of 100 ppm, with their promotion rates reaching 96.3% and 123.9%, 113.5% and 137.9%, 126.1% and 177.7%, 99.4% and 107.6%, respectively, indicating their potential as wheat growth promoters.