The Dark Side of NK Cells in Cancer Immunotherapy
NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.
Authors
- Belén Palencia (ORCID: https://orcid.org/0000-0002-8664-4856)
- María Armero (ORCID: https://orcid.org/0009-0005-7988-5685)
- David R. Withers (ORCID: https://orcid.org/0000-0003-3757-7594)
- Felipe Gálvez‐Cancino (ORCID: https://orcid.org/0000-0001-8417-1891)
- Ignacio Melero (ORCID: https://orcid.org/0000-0002-1360-348X)
- Paula Molero-Glez (ORCID: https://orcid.org/0009-0002-5679-8296)
- A. Melero
Institutions
- Nuffield Orthopaedic Centre (GB)
- University of Oxford (GB)
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Immune Regulation (United Kingdom) (GB)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-1042
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19