3D‐Printed Extracellular Matrix‐Mimicking Hydrogels Derived from Multiple Tissues for Integrated Construction of Complex Organs
Due to the lack of suitable donors and concerns about immune rejection after transplantation, the demand for artificial organs among patients is increasing. Extracellular matrix-mimicking hydrogels provide excellent prospects for overcoming the limitations of current artificial organ construction methods. Here, a set of extracellular matrix-mimicking hydrogels derived from multiple animal tissues is described, which meets the regeneration needs of multiple tissues after xenotransplantation. Combined with 3D printing technology, multiple extracellular matrix-mimicking hydrogels are used to prepare 3D layered hybrid structures to simulate complex organs with heterogeneous composition. In this process, the corresponding extracellular matrix-mimicking hydrogels participate in organ regeneration via their unique tissue-specific components. This strategy can potentially be extended to any complex organs with heterogeneous composition, providing the possibility for the manufacture of artificial organs based on animal tissues.
Authors
- Weiyan Sun (ORCID: https://orcid.org/0000-0002-5397-7857)
- Yulong Hu (ORCID: https://orcid.org/0000-0003-3844-3950)
- Minglei Yang (ORCID: https://orcid.org/0000-0002-6881-337X)
- Ziyin Pan
- Yunlang She (ORCID: https://orcid.org/0000-0001-7673-9846)
- Qingfeng Bai
- Dawei Li (ORCID: https://orcid.org/0000-0002-5138-4492)
- Yi Chen (ORCID: https://orcid.org/0000-0002-7887-0175)
- Lei Wang (ORCID: https://orcid.org/0000-0002-7584-8802)
- Chang Chen (ORCID: https://orcid.org/0000-0002-9981-3110)
- Hai Tang (ORCID: https://orcid.org/0000-0002-2300-1511)
- Guofang Zhao (ORCID: https://orcid.org/0000-0002-4172-1862)
- Runfeng Cao
- Bo-Wei Xu (ORCID: https://orcid.org/0009-0001-9286-5997)
- Weikang Lin (ORCID: https://orcid.org/0000-0003-1112-8336)
Institutions
- Jiangnan University (CN)
- Tongji University (CN)
- Fujian Medical University (CN)
- Ningbo No. 2 Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Ningbo Institute of Industrial Technology (CN)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1002/adhm.202502299
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Pulmonary Hospital