Electroacupuncture Pretreatment Alleviates Myocardial Ischemia–Reperfusion Injury by Inhibiting Engulfment by Microglia in the Lateral Hypothalamus
EA-pre inhibits microglial engulfment of inhibitory synapses around LH<sup>Glu</sup> neurons in MIRI mice, thereby suppressing LH<sup>Glu</sup> neuronal activity, reducing SNS output, and ultimately exerting cardioprotective effects.
Authors
- Chaonan Dong (ORCID: https://orcid.org/0000-0002-3320-1541)
- Qi Shu (ORCID: https://orcid.org/0000-0002-7322-0798)
- Bin Zhang (ORCID: https://orcid.org/0000-0001-7940-0661)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-5878-4536)
- Yan Wu (ORCID: https://orcid.org/0000-0002-8966-4975)
- Zhou Xiang (ORCID: https://orcid.org/0000-0003-1470-5805)
- Naixuan Wei (ORCID: https://orcid.org/0000-0002-4805-4767)
- Peiyi Yang (ORCID: https://orcid.org/0000-0002-0824-163X)
- Rong-Lin Cai (ORCID: https://orcid.org/0000-0001-5666-6280)
- Qing Yu (ORCID: https://orcid.org/0000-0002-1600-2647)
- Huimin Chang (ORCID: https://orcid.org/0000-0002-0129-3592)
- Wenjing Shao (ORCID: https://orcid.org/0009-0009-5180-1311)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Wuhu Fourth People Hospital (CN)
- Wuhu No 1 People's Hospital (CN)
- National Science Centre (PL)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/cns.70595
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province