Genome-wide polygenic risk score for estimated glomerular filtration slope predicts chronic kidney disease in a Taiwanese population
We constructed a genome-wide polygenic risk score for eGFR decline and externally validated its use in predicting CKD in another Taiwan population. Our eGFR slope polygenic risk score might be useful for clinical CKD risk assessment in future, especially for East Asians.
Authors
- Gwo‐Tsann Chuang (ORCID: https://orcid.org/0000-0002-9926-4967)
- Chia‐Ni Hsiung
- Sungji Moon (ORCID: https://orcid.org/0000-0002-6668-3065)
- Adriana M. Hung (ORCID: https://orcid.org/0000-0002-3203-1608)
- Kook‐Hwan Oh (ORCID: https://orcid.org/0000-0001-9525-2179)
- Yi‐Cheng Chang (ORCID: https://orcid.org/0000-0002-8077-5011)
- Cassianne Robinson‐Cohen (ORCID: https://orcid.org/0000-0003-4783-7046)
- Sue K. Park (ORCID: https://orcid.org/0000-0001-5002-9707)
- Tony Pan-Hou (ORCID: https://orcid.org/0009-0003-2185-8938)
- Wenyi Li (ORCID: https://orcid.org/0000-0003-3584-0301)
- Sangjun Lee (ORCID: https://orcid.org/0000-0003-4080-0494)
Institutions
- Seoul National University (KR)
- National Taiwan University (TW)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- National University College (PR)
- National Taiwan University Hospital (TW)
- Institute of Statistical Science, Academia Sinica (TW)
- National Yunlin University of Science and Technology (TW)
- Academia Sinica (TW)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Nephrology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1007/s40620-025-02380-9
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University Hospital