The interaction of Cu(II) and Zn(II) with peptide fragment of HSPB1 and its analogs
This study highlights the importance of His-131 and Glu-126 residues in Cu<sup>2+</sup> and Zn<sup>2+</sup> ion binding by peptide fragments of the HSPB1 protein. These residues are essential for both the stability of the complexes and the nature of their interaction with the metal ions. Analytical methods exploring complexation behavior across a pH range of 2-10 and in buffer solutions provide a comprehensive view of the thermodynamic properties of the studied systems. This enables the prediction of their behavior under diverse conditions.
Authors
- Agnieszka Szebesczyk (ORCID: https://orcid.org/0000-0003-3533-1988)
- Ettore Napolitano (ORCID: https://orcid.org/0000-0001-6160-1860)
- Domenica Musumeci (ORCID: https://orcid.org/0000-0001-7624-1933)
- Paulina Iwaniak (ORCID: https://orcid.org/0000-0001-6351-9772)
- H. P. Kukhtenko (ORCID: https://orcid.org/0000-0002-7914-8053)
Institutions
- Medical University of Lublin (PL)
- University of Opole (PL)
- National University of Pharmacy (UA)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fmolb.2025.1593661
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowe Centrum Nauki