Adaptive sampling methods facilitate the determination of reliable dataset sizes for evidence-based modeling

How can we be sure that there is sufficient data for our model, such that the predictions remain reliable on unseen data and the conclusions drawn from the fitted model would not vary significantly when using a different sample of the same size? We answer these and related questions through a systematic approach that examines the data size and the corresponding gains in accuracy. Assuming the sample data are drawn from a data pool with no data drift, the law of large numbers ensures that a model converges to its ground truth accuracy. Our approach provides a heuristic method for investigating the speed of convergence with respect to the size of the data sample. This relationship is estimated using sampling methods, which introduces a variation in the convergence speed results across different runs. To stabilize results-so that conclusions do not depend on the run-and extract the most reliable information encoded in the available data regarding convergence speed, the presented method automatically determines a sufficient number of repetitions to reduce sampling deviations below a predefined threshold, thereby ensuring the reliability of conclusions about the required amount of data.

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Publication Details

Journal
Frontiers in Bioinformatics
Published
2025-09-04
DOI
https://doi.org/10.3389/fbinf.2025.1528515
Citations
1
Primary Topic
Statistical Methods and Bayesian Inference
Type
article
Field-Weighted Citation Impact
2.63
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article

Adaptive sampling methods facilitate the determination of reliable dataset sizes for evidence-based modeling

Tim Breitenbach, Thomas Dandekar
1 citations
Frontiers in Bioinformatics
Statistical Methods and Bayesian Inference
2.63
article

Adaptive sampling methods facilitate the determination of reliable dataset sizes for evidence-based modeling

Tim Breitenbach, Thomas Dandekar
article en
1 citations

Abstract

How can we be sure that there is sufficient data for our model, such that the predictions remain reliable on unseen data and the conclusions drawn from the fitted model would not vary significantly when using a different sample of the same size? We answer these and related questions through a systematic approach that examines the data size and the corresponding gains in accuracy. Assuming the sample data are drawn from a data pool with no data drift, the law of large numbers ensures that a model converges to its ground truth accuracy. Our approach provides a heuristic method for investigating the speed of convergence with respect to the size of the data sample. This relationship is estimated using sampling methods, which introduces a variation in the convergence speed results across different runs. To stabilize results-so that conclusions do not depend on the run-and extract the most reliable information encoded in the available data regarding convergence speed, the presented method automatically determines a sufficient number of repetitions to reduce sampling deviations below a predefined threshold, thereby ensuring the reliability of conclusions about the required amount of data.

Frontiers in BioinformaticsVol. 5
University of Würzburg (DE)
Openalex Percentile: Top 9%
Statistical Methods and Bayesian Inference
2.63
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