Second-trimester Hemogram-derived Inflammatory Markers for the Prediction and Severity Stratification of SGA Fetuses Based on Doppler and Birthweight Percentiles

Objective: This study aimed to evaluate the predictive value of secondtrimester maternal hemogram parameters in identifying small for gestational age (SGA) fetuses and assessing the severity of SGA based on umbilical artery Doppler (UAD) findings and birthweight percentiles.Method: A total of 150 singleton pregnancies were retrospectively analyzed and divided into three groups: SGA with abnormal UAD, SGA with normal UAD, and non-SGA controls.Maternal white blood cell (WBC) count, neutrophil count, lymphocyte count, platelet count, neutrophil-tolymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were compared among groups.SGA cases were further stratified into 3 rd percentile (high risk) and 4 th -10 th percentile (lower risk) subgroups based on birthweight percentiles, categorizing them as high-risk and low-risk SGA.Results: Maternal WBC and neutrophil counts were significantly higher in SGA pregnancies compared to non-SGA controls (p<0.05).The highest WBC and neutrophil levels were observed in the SGA group with abnormal UAD and in fetuses 3 rd percentile.No significant differences were found in lymphocyte count, platelet count, NLR, or PLR across groups.A strong association was noted between elevated maternal WBC and markers of SGA severity, including lower gestational age at delivery, reduced birthweight, and abnormal Doppler findings.Ama: Bu alma, ikinci trimesterdeki maternal hemogram parametrelerinin, gestasyonel yaa gre kk (SGA) fetslerin tanmlanmasnda ve umbilikal arter Doppler (UAD) bulgular ile doum arl persentillerine gre SGA iddetinin deerlendirilmesindeki ngrc deerini aratrmay amalamtr.Yntem: Toplam 150 tekil gebelik retrospektif olarak analiz edildi ve gruba ayrld: anormal UAD bulgularna sahip SGA, normal UAD bulgularna sahip SGA ve SGA olmayan kontrol grubu.Gruplar arasnda maternal beyaz kan hcresi (WBC) says, ntrofil says, lenfosit says, trombosit says, ntrofil/lenfosit oran (NLR) ve trombosit/lenfosit oran (PLR) karlatrld.SGA olgular ayrca doum arl persentillerine gre 3.persentil (yksek riskli) ve 4-10.persentil (daha dk riskli) olmak zere iki alt gruba ayrld.Bulgular: SGA gebeliklerinde maternal WBC ve ntrofil saylar, SGA olmayan kontrol grubuna kyasla anlaml derecede yksekti (p<0,05).En yksek WBC ve ntrofil dzeyleri, anormal UAD bulgularna sahip SGA grubunda ve 3.persentildeki fetslerde gzlendi.Lenfosit says, trombosit says, NLR ve PLR asndan gruplar arasnda anlaml fark saptanmad.Artm maternal WBC dzeyleri ile daha dk doum haftas, azalm doum arl ve anormal Doppler bulgular gibi SGA iddet gstergeleri arasnda gl bir iliki gzlemlendi.