Structurally Flexible (Thiazol-2-ylidene)Pd(Allyl)Cl Complexes for Suzuki–Miyaura Cross-Coupling of Aryl Halides and Amides
This study introduces a new class of (NHC)Pd(allyl)Cl complexes featuring thiazol-2-ylidene ligands, which exhibit enhanced steric and electronic properties compared to those of traditional imidazol-2-ylidenes. These air-stable Pd(II)-NHC catalysts demonstrate superior reactivity in chemoselective Suzuki-Miyaura cross-couplings of aryl bromides and amides. Kinetic studies reveal their superior reactivity over traditional imidazol-2-ylidene-based complexes. The findings highlight the potential of thiazole-based carbenes in advancing Pd-catalyzed cross-coupling reactions.
Authors
- Nana Chen (ORCID: https://orcid.org/0009-0003-3105-1310)
- Jin Zhang (ORCID: https://orcid.org/0000-0002-6616-7087)
- Ruihong Wang (ORCID: https://orcid.org/0000-0001-8370-0106)
- Michal Szostak (ORCID: https://orcid.org/0000-0002-9650-9690)
- Xiao Han (ORCID: https://orcid.org/0000-0002-0544-4351)
- Li Sun (ORCID: https://orcid.org/0009-0006-6933-5759)
- Gaopeng Zhang (ORCID: https://orcid.org/0000-0003-2138-4974)
Institutions
- Rutgers, The State University of New Jersey (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Catalytic Materials (United States) (US)
- Kaili University (CN)
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c03118
- Citations
- 1
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Rutgers, The State University of New Jersey
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Education Department of Shaanxi Province
- National Institute of General Medical Sciences