Comparative effectiveness of anti-inflammatory and antiviral therapies on NLR and survival outcomes in severe COVID-19: multicenter retrospective study
Among the evaluated therapies, tocilizumab and oseltamivir showed a consistent trend of lower NLR values in both survivors and non-survivors, compared to those not receiving these treatments. These findings suggest that tocilizumab and oseltamivir may offer some efficacy in modulating immune response (as measured by NLR) and potentially improving outcomes. However, due to observed weak correlations no single therapy alone appears sufficient to predict or reduce mortality, emphasizing the need for multimodal treatment strategies and further investigation into combined biomarker models.
Authors
- Hamdan Albaqawi (ORCID: https://orcid.org/0000-0001-9749-9669)
- Hanan Alyami (ORCID: https://orcid.org/0000-0003-3176-2756)
- Muhammad Daniyal (ORCID: https://orcid.org/0000-0002-5663-5211)
- Bushra Alshammari (ORCID: https://orcid.org/0000-0001-9631-8870)
- Awad Al‐Omari (ORCID: https://orcid.org/0000-0002-4866-5330)
- Abbas Saleh Al Mutair (ORCID: https://orcid.org/0000-0002-9471-2767)
- Awatif Alrasheeday (ORCID: https://orcid.org/0000-0003-1157-8185)
- Kawthar Alsaleh (ORCID: https://orcid.org/0000-0003-1596-6732)
- Richard Mottershead (ORCID: https://orcid.org/0000-0003-0048-0553)
- Hanan Fahad Alharbi (ORCID: https://orcid.org/0000-0003-2500-6700)
- Sameer Abdulmalik Alkubati (ORCID: https://orcid.org/0000-0001-8538-5250)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Prince Sultan University (SA)
- University of Wollongong (AU)
- Saad Specialist Hospital (SA)
- University of Sharjah (AE)
- University of Ha'il (SA)
- Prince Sultan Military College of Health Sciences
- King Faisal University (SA)
Publication Details
- Journal
- PeerJ
- Published
- 2025-09-04
- DOI
- https://doi.org/10.7717/peerj.20003
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00