Recurrent FGFR2 and PIK3CA Mutations in Sialoblastoma
A distinct subset of sialoblastoma has FGFR2 p.C382R hotspot mutation as the predominant driver mutation. Tumors with this mutation tend to have solid growth pattern, aggressive histologic features, and clinical behavior. The identification of concurrent genomic alterations expands the molecular landscape of this rare tumor. The detection of alternative drivers, such as CTNNB1 hotspot mutations typical of basal cell adenoma, also suggests that a subset of sialoblastoma may represent other salivary gland tumors presenting in infancy.
Authors
- Quynh T. Tran (ORCID: https://orcid.org/0000-0001-9308-1775)
- Rita Alaggio (ORCID: https://orcid.org/0000-0003-3915-3816)
- Brent A. Orr (ORCID: https://orcid.org/0000-0003-0997-4728)
- Faizan Malik (ORCID: https://orcid.org/0000-0001-8597-5074)
- Selene C. Koo (ORCID: https://orcid.org/0000-0001-8459-2469)
- Benjamin J. Wilkins (ORCID: https://orcid.org/0000-0002-1797-7323)
- Alessandra Stracuzzi (ORCID: https://orcid.org/0000-0002-7762-196X)
- Jingqun Ma (ORCID: https://orcid.org/0000-0002-0079-6323)
- Pauline M. Chou (ORCID: https://orcid.org/0000-0002-1114-8305)
Institutions
- St. Jude Children's Research Hospital (US)
- Children's Hospital of Philadelphia (US)
- Bambino Gesù Children's Hospital (IT)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- Head and Neck Pathology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1007/s12105-025-01838-3
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- St. Jude Children's Research Hospital
- American Lebanese Syrian Associated Charities
- National Cancer Institute