Chizhiaroterpenoids A–C: Benzofused Rearranged Lanostane-Type Triterpenoids from <i>Ganoderma lucidum</i>

Chizhiaroterpenoids A-C (<b>1</b>-<b>3</b>), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (<b>1</b>), 6/6/6/6/7 (<b>2</b>), and 6/6/6/5/6 (<b>3</b>) ring systems, were isolated from <i>Ganoderma lucidum</i>. Their biosynthetic pathways were proposed. <b>1</b> and <b>3</b> suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice. Additionally, <b>2</b> and <b>3</b> inhibited cancer-associated fibroblast-mediated extracellular matrix remodeling by modulating laminin, suggesting potential anti-breast cancer effects.