Hemoglobin Oxygen Affinity Does Not Change in the Canine Model of Moderate Acute Normovolemic Hemodilution
With decreased Hb and hematocrit (HCT) levels during ANH, the temperature (T) and base excess (BE) decreased, while Cl<sup>-</sup> increased. Compared with baseline (BL), in hemodilution 1 (HCT decreased to 75% of the BL, H1) and hemodilution 2 (HCT decreased to 50% of the BL, H2), pH and HCO<sub>3</sub> <sup>-</sup> decreased. Methemoglobin (MetHb) levels in H2 were significantly higher than those in BL and H1. HOA-related parameters did not change significantly in moderate ANH. Factors that increase or decrease the <i>P</i> <sub>50</sub> offset each other, leaving the <i>P</i> <sub>50</sub> unchanged in moderate ANH. The <i>P</i> <sub>50</sub> obtained based on the two blood gas analyzers was consistent, but neither was consistent with <i>P</i> <sub>50</sub> derived from the ODC.
Authors
- Hong Zhou (ORCID: https://orcid.org/0000-0003-2987-7781)
- Weidan Li (ORCID: https://orcid.org/0000-0001-8508-4984)
- Ming Sheng (ORCID: https://orcid.org/0000-0002-6824-5923)
- Ying Wang (ORCID: https://orcid.org/0000-0003-3328-3222)
- Guoxing You
- Daoyuan Gao
- Lian Zhao (ORCID: https://orcid.org/0000-0002-9790-1256)
- Penglong Li (ORCID: https://orcid.org/0000-0003-2768-736X)
- Shiyu Tao
Institutions
- Academy of Military Medical Sciences (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1021/acsomega.5c05248
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China