In Vitro and In Vivo Evaluation of Wound Dressing Based on <scp>PCL</scp> Nanofibers Loaded With <i>Linum usitatissimum</i> Extract
ABSTRACT In the present study, we fabricated nanofibers‐based wound dressing containing Linum usitatissimum (LOH) extract. The nanofibers were fabricated and characterized using electrospinning (applied voltage: 20 kV, feeding rate: 0.5 mL/min, and tip‐to‐collector distance: 10 cm). The SEM results indicated that the fabricated nanofibers have a straight and uniform morphology, and the diameter of PCL nanofibers loaded with 5%, 10%, and 15% of extract was 335 ± 45 nm, 438 ± 79 nm, and 471 ± 76 nm, respectively. Moreover, the nanofibers have porosity values in the range of 40%–55%. The in vitro biological evaluations revealed that adding the extract improved the biological performance (antioxidant, hemocompatibility, and cytocompatibility) of the pure PCL nanofibers. The in vivo study showed that the fabricated nanofibers improved the induced wound's healing process and enhanced the tissue's antioxidant state. These observations showed that combining electrospun nanofibers with LOH extract resulted in interactive and bioactive wound dressing nanofibers.
Authors
- Mehdi Azizi (ORCID: https://orcid.org/0000-0003-0777-5530)
- Redouan Elboutachfaiti (ORCID: https://orcid.org/0000-0002-5772-8030)
- Hadi Kokabi (ORCID: https://orcid.org/0000-0002-9154-215X)
- Hadi Samadian (ORCID: https://orcid.org/0000-0002-2478-5709)
- Esmaeel Sharifi (ORCID: https://orcid.org/0000-0003-3400-3106)
- Emmanuel Petit (ORCID: https://orcid.org/0000-0003-1533-6909)
- Mahnaz Mohammadpour (ORCID: https://orcid.org/0000-0003-2474-7910)
- Soheila Zare (ORCID: https://orcid.org/0000-0002-4962-1153)
- Cédric Delattre (ORCID: https://orcid.org/0000-0003-3605-1929)
- Anthony Quéro (ORCID: https://orcid.org/0000-0002-2119-3089)
- Masoud Hamidi (ORCID: https://orcid.org/0000-0003-3847-4247)
Institutions
- Hamedan University of Medical Sciences (IR)
- Zanjan University of Medical Sciences (IR)
- Centre National de la Recherche Scientifique (FR)
- Tarbiat Modares University (IR)
- Institut Pascal (FR)
- Institut Universitaire de France (FR)
- Guilan University of Medical Sciences (IR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- University of Clermont Auvergne (FR)
- Biologie des Plantes et Innovation (FR)
- Université de Picardie Jules Verne (FR)
Publication Details
- Journal
- Journal of Applied Polymer Science
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1002/app.57929
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hamadan University of Medical Sciences