Mitochondrial sORF-Encoded Peptide MODICA Protects the Heart From Doxorubicin-Induced Cardiac Injury by Suppressing VDAC Oligomerization
Our study shows that the mitochondrial short open reading frame-encoded peptide MODICA alleviates DOX-induced cardiac dysfunction and may represent a therapeutic target against DOX cardiotoxicity.
Authors
- Yili Chen (ORCID: https://orcid.org/0000-0001-8455-9378)
- Jing‐Song Ou (ORCID: https://orcid.org/0000-0001-5517-3142)
- Zhan‐Peng Huang
- Huimin Zhou (ORCID: https://orcid.org/0000-0002-3736-1745)
- Tailai Du (ORCID: https://orcid.org/0000-0002-8762-5569)
- Jialing Wu (ORCID: https://orcid.org/0000-0002-7923-1930)
- Xinxue Liao (ORCID: https://orcid.org/0000-0001-7631-1866)
- Chen Liu (ORCID: https://orcid.org/0000-0002-9818-0454)
- Kang Li (ORCID: https://orcid.org/0000-0003-0355-4255)
- Xu He (ORCID: https://orcid.org/0000-0003-0241-6694)
- Yugang Dong (ORCID: https://orcid.org/0000-0002-3072-5040)
- Xingfeng Xu (ORCID: https://orcid.org/0000-0002-8026-2128)
- Youchen Yan
- Ting Xu (ORCID: https://orcid.org/0009-0004-1193-3073)
- Yan Li (ORCID: https://orcid.org/0000-0003-2450-3836)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1161/circheartfailure.125.013381
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39