Correlation between AMH levels and embryonic aneuploidy rate in PGT-A patients: a retrospective study

In the PGT-A population, advanced maternal age (AMA), recurrent spontaneous abortion (RSA), or recurrent implantation failure (RIF) have been identified as contributing factors. After adjusting for potential confounders such as female age, AMH remains a significant risk factor for embryonic aneuploidy rates. The findings suggested that lower AMH levels are associated with a higher risk of embryonic aneuploidy, indicating that ovarian reserve function may be correlated with oocyte quality. These results provide new insights for individualized decision-making in assisted reproduction. Trial registration ChiCTR2500099710 (03/27/2025).

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Publication Details

Journal
Journal of Assisted Reproduction and Genetics
Published
2025-09-04
DOI
https://doi.org/10.1007/s10815-025-03619-x
Primary Topic
Renal and related cancers
Type
article
Field-Weighted Citation Impact
0.00

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article

Correlation between AMH levels and embryonic aneuploidy rate in PGT-A patients: a retrospective study

Panpan Zhao, Kaixuan Sun, Qian Zhang, Yuexin Yu et al.
Journal of Assisted Reproduction and Genetics
Renal and related cancers
article

Correlation between AMH levels and embryonic aneuploidy rate in PGT-A patients: a retrospective study

Panpan Zhao, Kaixuan Sun, Qian Zhang, Yuexin Yu, Samuel Tang
article en

Abstract

In the PGT-A population, advanced maternal age (AMA), recurrent spontaneous abortion (RSA), or recurrent implantation failure (RIF) have been identified as contributing factors. After adjusting for potential confounders such as female age, AMH remains a significant risk factor for embryonic aneuploidy rates. The findings suggested that lower AMH levels are associated with a higher risk of embryonic aneuploidy, indicating that ovarian reserve function may be correlated with oocyte quality. These results provide new insights for individualized decision-making in assisted reproduction. Trial registration ChiCTR2500099710 (03/27/2025).

Journal of Assisted Reproduction and GeneticsVol. 42(11)
Northern Hospital (AU), General Hospital of Shenyang Military Region (CN), Jinzhou Medical University (CN)
Key Research and Development Program of Liaoning Province
Openalex Percentile: Top 79%
Renal and related cancers
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