Bioinformatics analysis identified TCP1 and NOTCH1 as potential target molecules to overcome 5-fluorouracil resistance in cholangiocarcinoma
The bioinformatic analysis and PCR results revealed that NOTCH1 and TCP1 might be associated with 5-FU resistance and serve as potential molecular targets to enhance 5-FU sensitivity in CCA cells.
Authors
- Charupong Saengboonmee (ORCID: https://orcid.org/0000-0003-1476-1129)
- Wunchana Seubwai (ORCID: https://orcid.org/0000-0002-9265-5113)
- Worachart Lert-itthiporn (ORCID: https://orcid.org/0000-0002-7223-0169)
- Raksawan Deenonpoe (ORCID: https://orcid.org/0000-0002-8387-6061)
- Sonexai Kidoikhammouan
- Sumalee Obchoei (ORCID: https://orcid.org/0000-0002-3001-0563)
- Sopit Wongkham
- Nopkamol Kanchanangkul
Institutions
- Prince of Songkla University (TH)
- Khon Kaen University (TH)
Publication Details
- Journal
- Advances in Clinical and Experimental Medicine
- Published
- 2025-09-04
- DOI
- https://doi.org/10.17219/acem/203446
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Khon Kaen University