Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled Psoriasis
Platelet aggregation and activation are increased in patients with controlled psoriatic disease, with the platelet transcriptome associated with proinflammatory, proatherothrombotic pathways, and cardiovascular risk. Our results warrant further investigation of platelet involvement promoting heightened cardiovascular disease in psoriasis.
Authors
- Kristen Lo Sicco (ORCID: https://orcid.org/0000-0002-5219-9803)
- Elliot Luttrell‐Williams (ORCID: https://orcid.org/0000-0003-4163-2445)
- Matthew Muller (ORCID: https://orcid.org/0000-0002-5079-1889)
- Joel M. Gelfand (ORCID: https://orcid.org/0000-0003-3480-2661)
- José U. Scher (ORCID: https://orcid.org/0000-0002-1072-6994)
- Kamelia Drenkova (ORCID: https://orcid.org/0000-0001-5278-4028)
- Brittany Weber (ORCID: https://orcid.org/0000-0002-0177-2091)
- Andrea L. Neimann (ORCID: https://orcid.org/0000-0002-9729-0109)
- Michael Garshick (ORCID: https://orcid.org/0000-0002-6649-3755)
- Jill P. Buyon (ORCID: https://orcid.org/0000-0002-3852-7129)
- Florencia Schlamp (ORCID: https://orcid.org/0000-0003-3319-6778)
- James G. Krueger (ORCID: https://orcid.org/0000-0002-3775-1778)
- Jeffrey S. Berger (ORCID: https://orcid.org/0000-0001-8216-4647)
- Filipp Kazatsker
- Isabelle Boothman
Institutions
- Brigham and Women's Hospital (US)
- Cardiovascular Research Center (BR)
- Taiwan Centers for Disease Control (TW)
- Norwegian Womens Public Health Association (NO)
- Center for Rheumatology (US)
- New York University (US)
- University of Pennsylvania (US)
- Rockefeller University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1161/atvbaha.125.322574
- Citations
- 2
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.59