Design of a Biocompatible Artificial Human Heart

This study proposes a design and initial validation of a biocompatible artificial human heart that mimics beating behavior. Advanced geometrical modelling in SolidWorks software (student version) and finite element analysis (FEA) using ANSYS 2024 (student version) has been made, including Neo-Hookean hyper elastic material i.e., medical-grade silicone for cardiac tissue replication. The design consists of four-chambers, where the chambers’ dimensions were optimized to maintain uniform pressurization. We observed controlled wall displacement and low stress under simulated physiological conditions with our model. These results provide the basis of the design to be used as an effective teaching platform for medical students and a platform to future progress toward an implantable circulatory assistance device. These findings provide deeper insights into cardiac biomechanics and represent a novel approach to managing a growing need for cardiac alternatives to transplantation. Additionally, the report details the application of pressure and records displacement and stress outcomes from FEA. Through integration of hyper elastic material behavior into the design framework, the research provided critical insights into the performance of silicone-based models, informing future experimental studies and clinical translation.

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Publication Details

Published
2025-08-18
DOI
https://doi.org/10.3390/materproc2025023023
Primary Topic
Tissue Engineering and Regenerative Medicine
Type
article
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article

Design of a Biocompatible Artificial Human Heart

Ali Turab Jafry, Amera Almas, Muhammad Wasi Ahmed, Danial Kamran et al.
Tissue Engineering and Regenerative Medicine
article

Design of a Biocompatible Artificial Human Heart

Ali Turab Jafry, Amera Almas, Muhammad Wasi Ahmed, Danial Kamran, Muhammad Awais
article en

Abstract

This study proposes a design and initial validation of a biocompatible artificial human heart that mimics beating behavior. Advanced geometrical modelling in SolidWorks software (student version) and finite element analysis (FEA) using ANSYS 2024 (student version) has been made, including Neo-Hookean hyper elastic material i.e., medical-grade silicone for cardiac tissue replication. The design consists of four-chambers, where the chambers’ dimensions were optimized to maintain uniform pressurization. We observed controlled wall displacement and low stress under simulated physiological conditions with our model. These results provide the basis of the design to be used as an effective teaching platform for medical students and a platform to future progress toward an implantable circulatory assistance device. These findings provide deeper insights into cardiac biomechanics and represent a novel approach to managing a growing need for cardiac alternatives to transplantation. Additionally, the report details the application of pressure and records displacement and stress outcomes from FEA. Through integration of hyper elastic material behavior into the design framework, the research provided critical insights into the performance of silicone-based models, informing future experimental studies and clinical translation.

Ghulam Ishaq Khan Institute of Engineering Sciences and Technology (PK)
Openalex Percentile: Top 62%
Tissue Engineering and Regenerative Medicine
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Design of a Biocompatible Artificial Human Heart — Ali Turab Jafry, Amera Almas, et al. · (2025) | TGRS Research Map | TGRS