G-CSF Mediates Increased Renal Neutrophils and Kidney Damage in a Psoriasis Mouse Model
Our findings demonstrate G-CSF-dependent increases in renal neutrophil accumulation and renal damage in a mouse model of psoriasis. Results suggest a novel link between chronic psoriasiform skin inflammation and renal damage via G-CSF-mediated granulopoiesis, providing new insight into interorgan communication in psoriasis and a potential new therapeutic target for the treatment of psoriasis-related renal dysfunction.
Authors
- Tzushan S. Yang (ORCID: https://orcid.org/0000-0002-0263-0386)
- Taseer Ahmad (ORCID: https://orcid.org/0000-0003-4545-9598)
- Jason M. Meyer (ORCID: https://orcid.org/0000-0003-1327-3510)
- Lam C. Tsoi (ORCID: https://orcid.org/0000-0003-1627-5722)
- Johann Eli Gudjonsson (ORCID: https://orcid.org/0000-0002-0080-0812)
- Nicole L. Ward (ORCID: https://orcid.org/0000-0003-1907-2621)
- Bianca Nguyen (ORCID: https://orcid.org/0000-0002-1032-5277)
- Ziche Chen (ORCID: https://orcid.org/0000-0003-4005-9261)
- Matthew R. Alexander (ORCID: https://orcid.org/0000-0003-4739-7204)
- Annet Kirabo (ORCID: https://orcid.org/0000-0001-8580-9359)
- Rachael Bogle (ORCID: https://orcid.org/0000-0003-3544-3023)
- Mohammad Saleem (ORCID: https://orcid.org/0000-0001-8091-8361)
- Garrett Tessmer
Institutions
- University of Sargodha (PK)
- Vanderbilt University (US)
- University of Michigan (US)
- Biology of Infection (FR)
- Michigan Medicine (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25111
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Vanderbilt University
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Cancer Institute
- National Center for Research Resources