Mild Hyperuricemia Attenuates Salt-Sensitive Hypertension and Kidney Damage
Our study demonstrates that in male, but not female, Dahl salt-sensitive rats, mild hyperuricemia accompanied by hyperuricosuria slowed the progression of salt-sensitive hypertension, potentially due to reduced kidney damage.
Authors
- Ashraf El‐Meanawy (ORCID: https://orcid.org/0000-0002-3114-5312)
- Christine A. Klemens (ORCID: https://orcid.org/0000-0002-0812-824X)
- Alexander Staruschenko (ORCID: https://orcid.org/0000-0002-5190-8356)
- Ruslan Bohovyk (ORCID: https://orcid.org/0000-0002-3999-4570)
- Adrian Zietara (ORCID: https://orcid.org/0000-0002-7465-060X)
- Oleg Palygin (ORCID: https://orcid.org/0000-0002-3680-5527)
- Ilse S. Daehn (ORCID: https://orcid.org/0000-0001-9915-5376)
- Timo Rieg (ORCID: https://orcid.org/0000-0001-6082-662X)
- Olha Kravtsova (ORCID: https://orcid.org/0000-0002-4280-9399)
- Lashodya V. Dissanayake (ORCID: https://orcid.org/0000-0002-2329-0931)
- Melissa Lowe (ORCID: https://orcid.org/0009-0001-3854-3559)
- Abigail Shapiro (ORCID: https://orcid.org/0009-0009-1311-0034)
- Vladislav Levchenko (ORCID: https://orcid.org/0000-0003-0771-8034)
- Vera Pasmanik
Institutions
- Medical University of South Carolina (US)
- Medical College of Wisconsin (US)
- University of South Florida (US)
- James A. Haley Veterans' Hospital (US)
- American Association of Kidney Patients (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25550
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Minnesota
- University of South Florida
- Children’s Hospital of Wisconsin Research Institute