Associations of Physical Frailty, Social Deficits, and Cognitive Impairment with Risk of 45 Incident Non-Communicable Diseases: The Mediating Role of Accelerated Biological Aging—A Prospective Cohort Study
Impairments in physical, social, and cognitive functions were associated with an increased risk of numerous NCDs, with accelerated biological aging partially mediating these associations, highlighting the importance of systematically assessing frailty and biological aging and implementing interventions to prevent NCDs.
Authors
- Yongyong Shi (ORCID: https://orcid.org/0000-0003-1710-1505)
- Yue Yu (ORCID: https://orcid.org/0000-0003-3452-8391)
- Xinyuan Shen (ORCID: https://orcid.org/0009-0008-0299-1158)
- Fulan Hu (ORCID: https://orcid.org/0000-0002-2386-1503)
- Bing Pei
- Fan Wang (ORCID: https://orcid.org/0000-0002-9869-9504)
- Yihan Zhang (ORCID: https://orcid.org/0000-0003-1566-5972)
- Jianping Wang (ORCID: https://orcid.org/0000-0002-6596-8771)
- Wenjing Wang (ORCID: https://orcid.org/0000-0002-4527-1168)
- Yanjie Jia (ORCID: https://orcid.org/0000-0001-8379-101X)
Institutions
- Harbin Medical University (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jnha.2025.100672
- Citations
- 2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.45