Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid Metabolism and Ferroptosis

Astaxanthin can regulate the metabolism of fatty acid through the ferroptosis pathway, and reduce the mitochondrial oxidative stress damage, and further regulate FADS2, Steap3, and other factors to promote spermatogenesis.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2025-09-01
DOI
https://doi.org/10.2147/dddt.s522738
Citations
2
Primary Topic
Antioxidant Activity and Oxidative Stress
Type
article
Field-Weighted Citation Impact
1.55
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article

Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid Metabolism and Ferroptosis

Zhiwei Liao, Xuren Chen, Silang Zhu, Ruilin Yang et al.
2 citations
Drug Design Development and Therapy
Antioxidant Activity and Oxidative Stress
1.55
article

Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid Metabolism and Ferroptosis

Zhiwei Liao, Xuren Chen, Silang Zhu, Ruilin Yang, Xuejun Ren, Xin Feng, Huang Liu, Tao Pang, Zhiyong Zhu
article en
2 citations

Abstract

Astaxanthin can regulate the metabolism of fatty acid through the ferroptosis pathway, and reduce the mitochondrial oxidative stress damage, and further regulate FADS2, Steap3, and other factors to promote spermatogenesis.

Drug Design Development and TherapyVol. Volume 19
Sun Yat-sen University (CN), National Health and Family Planning Commission (CN), Panyu District Central Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Department of Health of Guangdong Province (CN), Guangzhou Medical University Cancer Hospital (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 15%
Antioxidant Activity and Oxidative Stress
1.55
DOIOpen Access PDFOpenAlex
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Astaxanthin Promotes Spermatogenesis in Mice by Reducing Mitochondrial Oxidative Stress Damage and Regulating Fatty Acid Metabolism and Ferroptosis — Zhiwei Liao, Xuren Chen, et al. · Drug Design Development and Therapy (2025) | TGRS Research Map | TGRS