Targeted Lymph Node Immunization with Serotype-Specific Dengue VLP Vaccines Enhances Antibody Avidity and Specificity
These findings suggest that targeting individual LNs could be a promising method for enhancing both the specificity and potency of immune responses, particularly for flaviviruses. Targeting distinct LNs by direct administration of individual vaccines into distinct watersheds rather than individual lymph nodes will offer the opportunity to facilitate the approach in humans.
Authors
- Romano Josi
- Alessandro Pardini (ORCID: https://orcid.org/0009-0008-5493-8893)
- Monique Vogel (ORCID: https://orcid.org/0000-0002-5219-4033)
- Anne‐Cathrine S. Vogt
- Dominik A. Rothen (ORCID: https://orcid.org/0009-0001-3048-4478)
- Martin F. Bachmann (ORCID: https://orcid.org/0000-0003-4370-2099)
- Paul Engeroff (ORCID: https://orcid.org/0000-0002-3409-512X)
- Kaspars Tārs (ORCID: https://orcid.org/0000-0001-8421-9023)
- Mona O. Mohsen (ORCID: https://orcid.org/0000-0003-3510-9148)
- Sudip Kumar Dutta (ORCID: https://orcid.org/0009-0000-4991-6640)
- Pascal S. Krenger (ORCID: https://orcid.org/0009-0008-7074-3842)
- Byron Martina
Institutions
- University of Bern (CH)
- Latvian Biomedical Research and Study Centre (LV)
- University Hospital of Bern (CH)
- University of Oxford (GB)
- University of Curaçao (CW)
- Jenner Institute (GB)
Publication Details
- Journal
- Vaccines
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3390/vaccines13090941
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung