Sulbactam Concentration in Critically Ill Patients with Hospital-Acquired Pneumonia: A Comparisons Stratified by Normal and Augmented Renal Clearance

Patients with higher eGFR demonstrated decreased levels of sulbactam. Despite the discrepancy in GFR estimated by creatinine and cystatin C, both the two biomarkers yielded similar predictions of variability in serum sulbactam concentration. Currently, there is no evidence in this study indicating that differences in renal function affect treatment outcomes in critically ill patients without elevated creatinine levels. Further research is warranted to explore the influence of varying renal function-related pharmacokinetic fluctuations on antibiotic efficacy.