Xianglian Anchang Decoction Mitigates Ulcerative Colitis via Inhibition of TLR-4-Mediated Pyroptosis
XLAC alleviates UC inflammation and intestinal barrier damage by targeting TLR4 to inhibit NLRP3 inflammasome activation and GSDMD-mediated pyroptosis. This study provides mechanistic insights into the clinical efficacy of XLAC for UC treatment.
Authors
- Lishan Lu
- Tianyu Gao (ORCID: https://orcid.org/0000-0002-1860-7252)
- Xuetong Ren (ORCID: https://orcid.org/0000-0001-6151-1013)
- J. M.
- Yuhua Wang (ORCID: https://orcid.org/0009-0003-5099-8614)
- Yang Liu (ORCID: https://orcid.org/0000-0002-0367-8189)
- Haoyu Chen (ORCID: https://orcid.org/0000-0003-0676-4610)
- Yangang Wang (ORCID: https://orcid.org/0000-0003-1298-9963)
- Shixiong Zhang (ORCID: https://orcid.org/0000-0003-2526-6588)
- Haiyan Bai
Institutions
- Beijing University of Chinese Medicine (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s533936
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00