Effectiveness of a personalized obesity treatment program in children with concomitant lipid metabolism disorders

Background. Childhood obesity remains one of the leading medical and social challenges of the 21st century, associated with a high risk of developing dyslipidemia, insulin resistance, and future cardiovascular pathology. Personalized, multicomponent treatment approaches demonstrate higher efficacy compared to traditional universal schemes but require effectiveness assessment under practical implementation conditions. The purpose was to evaluate the clinical effectiveness of a personalized treatment program for children with obesity and concomitant lipid metabolism disorders, delivered through a short-term intensive inpatient intervention followed by home-based support. Materials and methods. The study included 25 adolescents aged 12–17 years with grade I–III obesity and signs of dyslipidemia. During 14 days in a specialized center, an individualized protocol was implemented, including rational nutrition, physical activity, balneo- and physiotherapy, psychological support, supplementation. Follow-up continued for 6 months. Anthropometric data, bioimpedance measurements, and laboratory markers (lipid profile, HOMA-IR, leptin, 25(OH)D, high-sensitivity C-reactive protein) were assessed, as well as motivational and behavioral changes. Results. By day 14, body mass index had decreased by an average of 2.2 kg/m2 (p < 0.001), body fat percentage by 1.8 %, leptin levels by 35.8 % (p < 0.01), triglycerides by 23 % (p < 0.05), and the atherogenic index decreased from 5.1 to 3.1. After 6 months, 78 % of participants maintained positive dynamics: body weight was 6.0 ± 2.3 kg, BMI was 25.8 kg/m2, with normalization of HOMA-IR and lipid profile in most cases. The compliance rate was 84 % that directly correlated with family involvement and the personalized nature of the intervention. The program’s outcomes were comparable to or exceeded those of the Holbæk program (Denmark). Conclusions. A short-term, individualized intervention program for adolescents with obesity and dyslipidemia can serve as an effective alternative to traditional long-term treatment regimens, especially in the context of active family participation. Ongoing home-based support is critically important for long-term maintenance of therapeutic effects.