Circulating T-Cell Receptor Excision Circles at Birth and Risk of Childhood Cancers
We did not observe consistent associations between TREC levels at birth and childhood cancer risk. A possible explanation for the lack of more clear-cut differences in TREC levels between cases and matched controls might be the complex etiology of childhood cancers. The results underscore the need for longitudinal studies that incorporate additional immune biomarkers to understand the immunologic basis of childhood cancer development.
Authors
- Jun Tao (ORCID: https://orcid.org/0000-0003-2899-0248)
- Nora Gottlieb (ORCID: https://orcid.org/0000-0001-9199-2321)
- Eric A. Engels (ORCID: https://orcid.org/0000-0003-0203-6958)
- Paul S. Albert (ORCID: https://orcid.org/0000-0003-1658-1068)
- Paige Miller (ORCID: https://orcid.org/0009-0007-2327-5823)
Institutions
- National Institutes of Health (US)
- Texas Department of State Health Services (US)
- Northern California Research (US)
- National Cancer Institute (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3390/cancers17172903
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of State
- Texas Department of State Health Services
- National Cancer Institute