Using adaptive optics to assess hyporeflective clump speed and size in age-related macular degeneration in the PINNACLE Study. (PINNACLE Study Report 6)
AOO can detect HRC movement in AMD in images captured a mean of 105.5 min apart. HRC size and movement speed are consistent with microglial cells, but may also represent RPE cells. HRCs appear larger in images of atrophy.
Authors
- Lars G. Fritsche (ORCID: https://orcid.org/0000-0002-2110-1690)
- Daniel Rueckert (ORCID: https://orcid.org/0000-0002-5683-5889)
- Syed Abbas Raza (ORCID: https://orcid.org/0000-0003-4270-7939)
- Ahmed M. Hagag (ORCID: https://orcid.org/0000-0002-3372-7885)
- Sophie Riedl (ORCID: https://orcid.org/0000-0003-0003-0886)
- Thomas R. Taylor (ORCID: https://orcid.org/0000-0001-7906-790X)
- Ursula Schmidt‐Erfurth (ORCID: https://orcid.org/0000-0002-7788-7311)
- Julia Mai (ORCID: https://orcid.org/0000-0002-0528-9742)
- Hendrik P. N. Scholl (ORCID: https://orcid.org/0000-0002-7312-0316)
- Dimitrios Kazantzis (ORCID: https://orcid.org/0000-0002-4145-8144)
- Sobha Sivaprasad (ORCID: https://orcid.org/0000-0001-8952-0659)
- Andrew Lotery (ORCID: https://orcid.org/0000-0001-5541-4305)
- Hrvoje Bogunović (ORCID: https://orcid.org/0000-0002-9168-0894)
- Naomi Wijesingha (ORCID: https://orcid.org/0000-0003-0206-1061)
- Christopher Holmes (ORCID: https://orcid.org/0000-0003-2018-3732)
Institutions
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- University of Basel (CH)
- University of Michigan (US)
- Boehringer Ingelheim (United Kingdom) (GB)
- Moorfields Eye Hospital (GB)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- University of Southampton (GB)
- University College London (GB)
- Imperial College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Eye
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1038/s41433-025-03951-7
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Wellcome Trust
- National Institute for Health and Care Research
- University College London
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Moorfields Eye Hospital NHS Foundation Trust