Evaluation of Neutrophil to Lymphocyte Ratio in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma Treated With a Combination of Cetuximab and Nivolumab in a Phase II Clinical Trial
Low OT-NLR and pretreatment T-NLR correlated with superior treatment outcomes in patients with R/M HNSCC treated with cetuximab and nivolumab. Further evaluation of T-NLR to improve patient selection and peripheral blood OT-NLR as a dynamic biomarker contributing to clinical benefit assessment given cetuximab and nivolumab is warranted.
Authors
- Marcelo Raul Bonomi (ORCID: https://orcid.org/0000-0002-9399-3608)
- Juan C. Hernandez‐Prera (ORCID: https://orcid.org/0000-0003-0809-4649)
- Robbert J.C. Slebos (ORCID: https://orcid.org/0000-0003-3117-9544)
- David Kaldas (ORCID: https://orcid.org/0000-0002-4725-1566)
- Antonio L. Amelio (ORCID: https://orcid.org/0000-0002-6295-2694)
- Tyler J. Kristoff (ORCID: https://orcid.org/0000-0001-7224-7123)
- Christine H. Chung (ORCID: https://orcid.org/0000-0001-5199-4306)
- James William Rocco (ORCID: https://orcid.org/0000-0001-5312-0303)
- Joaquim M. Farinhas (ORCID: https://orcid.org/0000-0003-1040-7894)
- Kedar Kirtane (ORCID: https://orcid.org/0000-0003-1302-9577)
- Nabil F. Saba (ORCID: https://orcid.org/0000-0003-4972-1477)
- Fahad Rind (ORCID: https://orcid.org/0000-0003-3366-886X)
- Michael J. Schell (ORCID: https://orcid.org/0000-0003-4594-6601)
- Robin Park (ORCID: https://orcid.org/0000-0002-3004-3285)
- Ritu Chaudhary (ORCID: https://orcid.org/0009-0007-9417-0340)
- Sowjanya Thatikonda (ORCID: https://orcid.org/0000-0002-5353-7202)
- Conor Steuer (ORCID: https://orcid.org/0000-0001-6528-6319)
- Priyanka Bhateja (ORCID: https://orcid.org/0000-0001-9515-0498)
- Yeva Meshkovska
- Hyun‐Su Kim (ORCID: https://orcid.org/0000-0003-4410-3274)
- MacLean S. Hall
- Jiannong Li
- Maria I. Biernacki
Institutions
- Emory University (US)
- Nova Southeastern University (US)
- University of South Florida (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Endocrine Society (US)
- Moffitt Cancer Center (US)
- Diabetes & Endocrine Associates (US)
Publication Details
- Journal
- American Journal of Clinical Oncology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1097/coc.0000000000001255
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00