Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment (Adv. Sci. 33/2025)
Penile SquamouS Cell CarCinomaThe image illustrates a spatially resolved atlas of penile epithelial differentiation, revealing how tumor cells in penile squamous cell carcinoma (PSCC) mimic the developmental trajectory of normal epithelium.In article number 2500216, Wanhai Xu and co-workers identify the Tum_1 subtype, defined by basal stem-like features and elevated invasive potential.
Authors
- Wanhai Xu (ORCID: https://orcid.org/0000-0003-3442-7988)
- Hongxue Meng (ORCID: https://orcid.org/0000-0002-1831-2737)
- Guoxi Xie (ORCID: https://orcid.org/0000-0002-4842-7252)
- Guibo Li (ORCID: https://orcid.org/0000-0002-6141-4931)
- Yubo Zhao (ORCID: https://orcid.org/0000-0001-9665-0769)
- Roman Nawroth (ORCID: https://orcid.org/0000-0001-9361-7947)
- Pengyu Guo (ORCID: https://orcid.org/0000-0002-2398-8491)
- Dexin Ding (ORCID: https://orcid.org/0000-0002-7304-4376)
- Qing Shi
- Yaowei Li (ORCID: https://orcid.org/0000-0003-0725-6108)
- Hongjian Song (ORCID: https://orcid.org/0000-0001-7105-1196)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-9040-3289)
- Yu Qiu (ORCID: https://orcid.org/0000-0003-1069-4520)
- Ziqing Deng (ORCID: https://orcid.org/0000-0001-8726-0160)
- Zhihao Yin (ORCID: https://orcid.org/0000-0002-1193-1869)
- Da‐Yong Hou (ORCID: https://orcid.org/0000-0002-7567-8663)
- Peng Zhang (ORCID: https://orcid.org/0000-0003-1771-7545)
- Ziyi Liu (ORCID: https://orcid.org/0000-0002-0302-1099)
- Ziqi Wang (ORCID: https://orcid.org/0000-0002-4353-2176)
- Zongzheng Yang
- Peng Dai (ORCID: https://orcid.org/0000-0002-5973-9155)
- Yongsheng Chen (ORCID: https://orcid.org/0000-0003-1448-8177)
- Zhichao Tong
- Di Wang (ORCID: https://orcid.org/0009-0001-0371-010X)
- Fang Fan (ORCID: https://orcid.org/0000-0002-5791-452X)
- Wen Feng (ORCID: https://orcid.org/0000-0001-8485-5345)
- Tao Xu (ORCID: https://orcid.org/0000-0001-8022-5987)
- Liang Wu (ORCID: https://orcid.org/0000-0003-1721-2117)
- Zhenwei Zhang (ORCID: https://orcid.org/0000-0001-5528-1792)
- Changfu Li (ORCID: https://orcid.org/0009-0007-9860-8485)
- Xin Hu (ORCID: https://orcid.org/0000-0002-3737-2786)
- Yangyang Xu (ORCID: https://orcid.org/0000-0001-8448-1443)
- Hang Su (ORCID: https://orcid.org/0000-0003-2752-5862)
- Lichen Teng
- Jianzhang Li
- Wentao Liu (ORCID: https://orcid.org/0009-0008-9257-8155)
- Jianwei Wang
- Haonan Li (ORCID: https://orcid.org/0009-0004-1982-8710)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/advs.71432
- Citations
- 2
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 4.01