Case Report: Multimodal management of a rare pediatric astroblastoma using proton beam therapy and Gamma Knife radiosurgery—a case report and literature review
This case suggests that leveraging the tissue-sparing benefits of initial PBT may enable effective salvage SRS for managing residual or recurrent high-grade pediatric astroblastoma. Furthermore, it highlights the potential role of molecular profiling to guide targeted therapies in these rare tumors.
Authors
- Weihai Ning
- Masashi Mizumoto (ORCID: https://orcid.org/0000-0001-7837-1301)
- Yang Lü (ORCID: https://orcid.org/0000-0001-9571-4679)
- Yuanyang Nie
- Shosei Shimizu (ORCID: https://orcid.org/0000-0001-6298-9713)
- Xinfa Wang (ORCID: https://orcid.org/0000-0002-6293-5624)
- Yonglong Jin
- Wei Wang
- Jie Wang (ORCID: https://orcid.org/0000-0002-2567-8761)
- Jun Zhao (ORCID: https://orcid.org/0000-0003-1464-7158)
- Yan Zou (ORCID: https://orcid.org/0000-0002-2307-1376)
- Jingjing Kong (ORCID: https://orcid.org/0000-0003-3370-9756)
- Jianfeng Liang (ORCID: https://orcid.org/0000-0003-1657-0115)
- Dongxue Zhou
- Xijia Zhang
- Zishen Wang
Institutions
- Qingdao University (CN)
- University of Tsukuba (JP)
- Peking University (CN)
- Beijing Tian Tan Hospital (CN)
- Hospital of Hebei Province (CN)
- Nanjing Children's Hospital (CN)
- Beijing Sanbo Brain Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fonc.2025.1620637
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63