Neoadjuvant Chemotherapy Without Radiation for Locally Advanced Rectal Cancer: A Meta-analysis of Surgical Outcomes After Total Mesorectal Excision
Important surgical outcomes were not reported in trials comparing neoadjuvant chemotherapy alone to chemoradiation therapy for locally advanced rectal cancer. Based on the limited data available, chemotherapy alone was associated with reduced risk of anastomotic leak, diverting ostomy use, and ostomy nonreversal. See Video Abstract .
Authors
- Dean Fergusson (ORCID: https://orcid.org/0000-0002-3389-2485)
- Saba Balvardi (ORCID: https://orcid.org/0000-0002-5530-3979)
- Marylise Boutros
- Richard Garfinkle
Institutions
- University of Ottawa (CA)
- AdventHealth Orlando (US)
- Adventist University of Health Sciences (US)
- Ottawa Hospital (CA)
- Jewish General Hospital (CA)
- Cleveland Clinic Florida (US)
- Ottawa Hospital Research Institute (CA)
Publication Details
- Journal
- Diseases of the Colon & Rectum
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1097/dcr.0000000000003946
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05