Inhibition of HMGB1/NF-κB signaling restores Th17/Treg balance via dendritic cell modulation in liver transplant rejection
HMGB1 drives DC-mediated Th17/Treg imbalance during LT rejection through NF-κB activation. Targeting this pathway may offer a novel immunomodulatory strategy for managing AR.
Authors
- Linyu Li (ORCID: https://orcid.org/0000-0002-8419-0133)
- Yi Chen (ORCID: https://orcid.org/0000-0003-3262-3627)
- Liyun Huang (ORCID: https://orcid.org/0009-0003-0579-0080)
- Lihong Chen (ORCID: https://orcid.org/0000-0002-2302-6890)
- Jie Wang (ORCID: https://orcid.org/0009-0008-9381-4594)
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1649366
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Fujian Medical University