ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway (Adv. Sci. 33/2025)
STAU2-ASO TherApy fOr pAncreATic DUcTAl ADenOcArcinOmAThe cover is inspired by the Chinese mythological novel Journey to the West.The Monkey King wields weapon with STAU2-ASO to targeting strike STAU2 (monster's torso) -PALLD (monster's tail).The absence of STAU2 leads to PALLD RNA degradation (tail disintegration), thereby inhibiting the metastasis of tumor cells (stones in monster's hands and on the mountain) from the pancreas (ochre mountain) to the liver (reddish-brown mountain).
Authors
- Wenbin Kuang
- Wenjian Min (ORCID: https://orcid.org/0000-0002-0519-0654)
- Bangbang Li
- Jiayu Ding (ORCID: https://orcid.org/0000-0001-9264-218X)
- Zhongrui Shi (ORCID: https://orcid.org/0000-0001-7630-3268)
- Yasheng Zhu (ORCID: https://orcid.org/0009-0009-6843-1433)
- Yiping Hou (ORCID: https://orcid.org/0000-0003-4254-2388)
- Shun‐Qing Liang (ORCID: https://orcid.org/0000-0003-4664-6029)
- Peng Yang (ORCID: https://orcid.org/0000-0003-1535-2538)
- Kai Yuan (ORCID: https://orcid.org/0000-0001-7002-5703)
- Jiaying Ji
- Jia Li (ORCID: https://orcid.org/0000-0002-4434-7888)
- Liping Wang (ORCID: https://orcid.org/0000-0001-6893-3809)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-7848-9585)
- Xuejiao Wang (ORCID: https://orcid.org/0000-0003-4824-7312)
- Hao Shen (ORCID: https://orcid.org/0000-0002-8557-8973)
- Chengliang Sun (ORCID: https://orcid.org/0000-0002-8428-0091)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/advs.71431
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00