The gut–liver axis in progressive steatotic liver disease: A focus on bile acid dysregulation
Taurocholate and taurochenodeoxycholate emerge as consistent BA markers across liver disease stages, suggesting BA metabolism as potential therapeutic targets. This multi-model study bridges knowledge gaps in BA-driven mechanisms, informing personalised strategies for SLD management.
Authors
- Joanna Simpson (ORCID: https://orcid.org/0000-0002-0939-8487)
- Panayiotis Louca (ORCID: https://orcid.org/0000-0001-5956-1433)
- Francisco Javier Cubero
- Ana M. Valdes (ORCID: https://orcid.org/0000-0003-1141-4471)
- Olga Estévez‐Vázquez (ORCID: https://orcid.org/0000-0002-7983-8521)
- María Martínez-Gómez (ORCID: https://orcid.org/0009-0008-4176-1056)
- Juan M. Pericàs (ORCID: https://orcid.org/0000-0002-3645-3293)
- Natalie Z M Homer (ORCID: https://orcid.org/0000-0002-9262-2098)
- Afroditi Kouraki (ORCID: https://orcid.org/0000-0002-5976-9047)
- Cristina Menni (ORCID: https://orcid.org/0000-0001-9790-0571)
- Yu Lin (ORCID: https://orcid.org/0000-0002-5583-4374)
- M Serra Cusidó
Institutions
- Hebron University (PS)
- Nottingham University Hospitals NHS Trust (GB)
- King's College London (GB)
- Nottingham City Hospital (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Vall d'Hebron Institut de Recerca (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Nottingham Biomedical Research Centre (GB)
- Medical Research Network (US)
- The Queen's Medical Research Institute (GB)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jnha.2025.100671
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Wellcome Trust
- UK Research and Innovation
- Dipartimenti di Eccellenza
- National Institute for Health and Care Research
- British Heart Foundation
- European Commission
- Ministero della Salute
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme
- Medical Research Council
- Agencia Estatal de Investigación
- NIHR Nottingham Biomedical Research Centre