ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling (Adv. Sci. 33/2025)
Tumor Immune mIcroenvIronmenTCan we maximize antitumor potency with minimal toxicity in colorectal cancer?This cover shows the "Winged Tiger" concept: FK866 represents the tiger, C188-9 its wings, and the tiger's boxing gloves symbolize an ROS-responsive hydrogel delivering drugs locally.With ROS-sensing goggles, the tiger locates ROS-high, boxing-gloved tumors and unleashes punches to crush cancer in situ.More details can be found in article number 2506599 by Ying Yua, Ji Wang, Chenyang Ye, and co-workers
Authors
- Mi Mi
- Ying Yuan (ORCID: https://orcid.org/0000-0002-3922-9553)
- Chenyang Ye (ORCID: https://orcid.org/0000-0002-3695-6309)
- Shanshan Weng (ORCID: https://orcid.org/0000-0001-7595-1458)
- Saimeng Shi
- Cheng Guo (ORCID: https://orcid.org/0000-0001-6194-1232)
- Lu Wang (ORCID: https://orcid.org/0009-0009-4786-4651)
- Chao Chen (ORCID: https://orcid.org/0000-0002-4422-1716)
- Lina Qi
- Rui Bai (ORCID: https://orcid.org/0000-0003-4982-7562)
- Ji Wang (ORCID: https://orcid.org/0000-0002-7771-5819)
- Xuefeng Fang
- Yier Lu
- Yinuo Tan
- Mengyuan Yang (ORCID: https://orcid.org/0009-0005-2342-0993)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/advs.71424
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04