Inhibition of YB-1 phosphorylation enhances cisplatin activity and disrupts cell division in pleural mesothelioma
The serine 102 phosphorylated form of YB-1 contributes to the malignant phenotype of PM. Inhibition of YB-1 phosphorylation warrants further exploration as part of treatment strategies for this devastating disease.
Authors
- Glen Reid (ORCID: https://orcid.org/0000-0001-6465-5223)
- Anna Solta (ORCID: https://orcid.org/0000-0002-5164-010X)
- Benjamin Zitta
- Dominik Emminger (ORCID: https://orcid.org/0000-0002-0687-5778)
- Mir Alireza Hoda (ORCID: https://orcid.org/0000-0002-7088-8768)
- Gerald Timelthaler (ORCID: https://orcid.org/0000-0002-0260-089X)
- Verena Kopatz (ORCID: https://orcid.org/0000-0002-7512-1398)
- Michael Grusch (ORCID: https://orcid.org/0000-0001-5486-9340)
- Walter Berger (ORCID: https://orcid.org/0000-0003-0014-1658)
- Karin Schelch (ORCID: https://orcid.org/0000-0001-8742-1737)
- Balázs Döme (ORCID: https://orcid.org/0000-0001-8799-8624)
- Dominik Kirchhofer
- Clemens Aigner (ORCID: https://orcid.org/0000-0002-7787-991X)
- Nadine Maach
- Muhammad Hashim (ORCID: https://orcid.org/0000-0001-6262-8176)
Institutions
- Semmelweis University (HU)
- Lund University (SE)
- Dunedin Public Hospital (NZ)
- Comprehensive Cancer Center Vienna (AT)
- National Institute of Oncology (HU)
- Maurice Wilkins Centre (NZ)
- Országos Korányi Tbc és Pulmonológiai Intézet (HU)
- Medical University of Vienna (AT)
- University of Otago (NZ)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1038/s41416-025-03177-0
- Citations
- 1
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Austrian Science Fund
- Universität Wien
- Higher Education Commission, Pakistan
- Medizinische Universität Wien