Immune and Growth Factor Signaling Pathways Are Associated with Pathologic Complete Response to an Anti–Type I Insulin-like Growth Factor Receptor Regimen in Patients with Breast Cancer
Activation status of IGF-1R/IR associated with increased pCR to PGM in HR+ breast cancers. Immune activation markers were also associated with response in HR+ and HR- subgroups. Thus, IGF-1R may directly regulate tumor biology and associate with immune response to therapy.
Authors
- Denise M. Wolf (ORCID: https://orcid.org/0000-0002-3676-653X)
- Laura van ‘t Veer (ORCID: https://orcid.org/0000-0002-9838-8298)
- Lamorna Brown Swigart (ORCID: https://orcid.org/0000-0003-2076-5177)
- Julia Wulfkuhle (ORCID: https://orcid.org/0000-0002-0657-692X)
- Douglas Yee (ORCID: https://orcid.org/0000-0002-3387-4009)
- Rosa I. Gallagher (ORCID: https://orcid.org/0000-0003-3887-8399)
- Christina Yau (ORCID: https://orcid.org/0000-0002-1937-0859)
- Laura J. Esserman (ORCID: https://orcid.org/0000-0001-9202-4568)
- Gillian L. Hirst (ORCID: https://orcid.org/0000-0002-4502-0035)
- Emanuel F. Petricoin (ORCID: https://orcid.org/0000-0001-8787-5990)
Institutions
- University of Minnesota (US)
- George Mason University (US)
- University of California, San Francisco (US)
- University of San Francisco (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0553
- Citations
- 3
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- National Cancer Institute