Photocatalytic Synthesis of 1,2-Sulfinate-Sulfonate Esters by Four-Component Radical-Polar Crossover Cyclization
Structurally diverse 1,2-sulfinate-sulfonate esters are shown to be conveniently prepared through visible light-induced sulfonation and sulfinylation of difunctionalized alkenes using alcohols and NaHSO<sub>3</sub>. The reactions proceed under mild conditions in the presence of photocatalysts and HCO<sub>2</sub>H as an additive, exhibiting good functional group tolerance and a broad scope. Furthermore, this method is scalable and has been successfully applied to synthesize 1,2-disulfonic acid esters. A plausible mechanistic pathway has been proposed based on control experiments.
Authors
- Ligang Huang (ORCID: https://orcid.org/0000-0002-2569-0947)
- Xu Zhou (ORCID: https://orcid.org/0000-0001-5497-5960)
- Hui Xu (ORCID: https://orcid.org/0000-0003-1999-9806)
- Chao Shu (ORCID: https://orcid.org/0000-0002-4722-2714)
- Yongxin Zhang (ORCID: https://orcid.org/0000-0002-4968-5122)
- Xing Fang
Institutions
- Central China Normal University (CN)
- Ministry of Education (ME)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c03152
- Citations
- 3
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Central China Normal University
- Department of Science and Technology, Hubei Provincial People's Government
- National Key Research and Development Program of China