Tissue Architecture Modulates Compositional and Structural Properties of Corneal Myofibroblast-Derived Matrix

We developed a three-dimensional in vitro model that closely mimics in vivo conditions to investigate the role of corneal myofibroblasts in healing and regeneration. Ultimately, this model can help develop targeted antifibrotic therapies to prevent corneal scarring.

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Publication Details

Journal
Translational Vision Science & Technology
Published
2025-09-04
DOI
https://doi.org/10.1167/tvst.14.9.9
Primary Topic
Corneal Surgery and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Tissue Architecture Modulates Compositional and Structural Properties of Corneal Myofibroblast-Derived Matrix

Ludvig J. Backman, Patrik Danielson, Antonios Giannopoulos
Translational Vision Science & Technology
Corneal Surgery and Treatments
article

Tissue Architecture Modulates Compositional and Structural Properties of Corneal Myofibroblast-Derived Matrix

Ludvig J. Backman, Patrik Danielson, Antonios Giannopoulos
article en

Abstract

We developed a three-dimensional in vitro model that closely mimics in vivo conditions to investigate the role of corneal myofibroblasts in healing and regeneration. Ultimately, this model can help develop targeted antifibrotic therapies to prevent corneal scarring.

Translational Vision Science & TechnologyVol. 14(9)
Umeå University (SE)
Ögonfonden, Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för Synskadade, Vetenskapsrådet, Umeå Universitet
Openalex Percentile: Top 67%
Corneal Surgery and Treatments
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